What long do polynucleotides take to work?

To fully understand this question, we need to understand what polynucleotides are, their mode of action and how many treatments are required:

Polynucleotides are a regenerative medicinal treatment which stimulate the natural reconstruction and repair of damaged tissue. Polynucleotides harness filtered, ultra-purified and sterilised natural DNA fractions which initiate your body’s natural fibroblast production.

This, in turn reduces inflammation and encourages the production of the skin’s natural proteins: hyaluronic acid, collagen and elastin. In short, polynucleotides “reawaken” the skin’s natural healing and regeneration processes, helping improve texture, elasticity, and radiance working at a DNA level. It stands to reason then that this process takes time. Find out more here https://www.glamourmagazine.co.uk/article/salmon-sperm-facial-polynucleotides

How many sessions are required?

At least 2 sessions 14 days apart. Some people may need up to 4 sessions. Much depends on the degree of ageing the tissue has and the ability to create quality tissue when stimulated. Many people combine polynucleotides treatment with skin boosters (alternating treatments each week). This way they achieve an immediate and long-term effect.

How long do results last?

Polynucleotides can last for different lengths of time in different parts of the face, depending on various factors:

1. Blood flow and metabolism

• Areas with higher vascularity (like the cheeks or lips) tend to have faster turnover of injected materials

• Areas with less blood flow (like under the eyes or along the temples) often hold onto polynucleotides longer because breakdown and clearance happen more slowly

2. Movement and muscle activity

• Dynamic regions (forehead, around the eyes, mouth) are constantly moving — this mechanical stress can make polynucleotide-based treatments degrade or disperse more quickly.

• Still areas (like the lateral cheeks) tend to maintain results for longer.

3. Skin thickness and structure

• Thinner skin (periorbital area) may absorb and metabolize injected material differently than thicker skin (cheeks, jawline)

4. Individual factors

• Age, skin condition, smoking, hydration, and overall metabolism all affect how long the results last as this affects the product’s ability to integrate with the skin 

Typical duration:

• On average, polynucleotides can last around 4–6 months, but in low-movement areas, you might see results persisting up to 8–9 months

• Around dynamic areas such as the mouth and side of the eyes, effects may fade sooner (3–4 months)

When are results visible?

Results will be visible from around 12 weeks (and sometimes notably longer) after the end of the course of treatment. This is because they work on a cellular level over time, rather than acting like dermal fillers which replace lost volume in the short term.